| Gene Symbol | MDC1 |
| Full Name | Mediator of DNA Damage Checkpoint 1 |
| Function | MDC1 is a key mediator protein in the DNA damage response (DDR) pathway. |
| Ensembl ID | ENSG00000137336 |
| GeneCards | MDC1 |
| Human Protein Atlas | MDC1 |
| FHA Domain | Forkhead-associated domain for protein interactions |
| BRCT Domains | Breast cancer C-terminal domains for phospho-Ser/Thr binding |
| SDT Repeats | Ser-Asp-Thr repeats for ATM phosphorylation sites |
| NBS1-Binding Region | Mediates interaction with NBS1/MRE11/RAD50 complex |
| DNA Repair Impairment | AD neurons show reduced DNA repair capacity |
| Genomic Instability | Accumulation of DNA damage in AD brain |
| Therapeutic Target | Enhancing MDC1 function may protect neurons |
| Dopaminergic Neurons | Particularly vulnerable to DNA damage |
| Mitochondrial DNA | Links to mitochondrial dysfunction in PD |
| Associated Diseases | Als, Ataxia, Infection |
| Interactions | ATM, BRCA1, CANCER, RNF8 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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