| Gene Symbol | TH |
| Full Name | Tyrosine Hydroxylase |
| Chromosome | 11p15.5 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Enzyme replacement therapy via L-DOPA supplementation to bypass reduced TH activity |
| Druggability | Medium (0.54) |
| Clinical Stage | Approved |
| Pathways | MAPK |
| UniProt ID | E7EQI0 |
| NCBI Gene ID | 7067 |
| Ensembl ID | ENSG00000180176 |
| OMIM | 191290 |
| GeneCards | TH |
| Human Protein Atlas | TH |
| Associated Diseases | AUTOPHAGY, DOPAMINE, ER STRESS, FIBROSIS, FRONTOTEMPORAL DEMENTIA, INFLAMMATION |
| Known Drugs/Compounds | curcumin, dimethyl fumarate, L-DOPA, levodopa, LEVODOPA, rapamycin |
| Interactions | AADC, ACHE, AD, AIF, AKT, AMPK |
| SciDEX Target | View Target Profile (8 clinical trials) |
| KG Connections | 742 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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