gene 2,912 words KG: SORL1
Contents

SORL1 Gene

🧬 Gene Info
Gene SymbolSORL1
Full NameSortilin-Related Receptor 1 (Sorterin)
AliasesSortilin-Related Receptor 1
Chromosome11q23.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain, particularly in neurons of the hippocampus, cortex, and cerebel
Molecular Weight250 kDa
Amino Acids214 aa
Exons48
PathwaysAmyloid, Blood-Brain Barrier, Dysbiosis, Endocytosis, Epigenetic
UniProt IDQ92606
NCBI Gene ID6653
Ensembl IDENSG00000137642
OMIM602215
GeneCardsSORL1
Human Protein AtlasSORL1
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease
InteractionsABCA7, ABCB1, ACE, Actin, ALZHEIMER, ALZHEIMER DISEASE
KG Connections732 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
← Prevpg 2/2

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (8)

ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SOAT1 associated_with SORL1
SORL1 associated_with LRP12
PRKN interacts_with SORL1
SORL1 interacts_with BACE1
SORL1 interacts_with APP
SORL1 interacts_with APOE
SORL1 interacts_with TAU
SORL1 interacts_with SNCA
SORL1 interacts_with SNCAIP
SORL1 interacts_with GSK3B

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