| Gene Symbol | CASP4 |
| Full Name | Caspase-4 |
| Chromosome | 11q22.2 |
| Protein Family | Caspase family, inflammatory caspases (CASP1, CASP4, CASP5) |
| Protein Type | Protease |
| Function | Under conditions of ER stress, such as accumulation of misfolded proteins, CASP4 can be activated directly without inflammasome assembly. |
| Primary Expression | Broad, high in immune cells, CNS neurons and glia |
| Subcellular Localization | Cytoplasm, ER membrane, mitochondria |
| Molecular Weight | 45 kDa |
| Pathways | Mitochondrial Function, Oxidative Stress, pyroptosis |
| UniProt ID | P49662 |
| Ensembl ID | ENSG00000100994 |
| GeneCards | CASP4 |
| Human Protein Atlas | CASP4 |
| Prodomain | Long prodomain containing death effector domain (DED) for protein-protein interactions |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, Dementia, Multiple Sclerosis |
| Interactions | Actin, ALZHEIMER, Amyloid, ATP, AUTOPHAGY, CASP1 |
| KG Connections | 155 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!