gene 2,084 words KG: IDS
Contents

IDS — Iduronate Sulfatase

🧬 Gene Info
Gene SymbolIDS
Full NameIduronate Sulfatase
ChromosomeXq28
Protein TypeEnzyme
FunctionIduronate sulfatase is a member of the sulfatase family of enzymes that share a common mechanism of post-translational modification.
Primary Expressionmost tissues:
Amino Acids550 aa
Exons9
UniProt IDP22304
NCBI Gene ID3423
Ensembl IDENSG00000010373
OMIM309900
GeneCardsIDS
Human Protein AtlasIDS
Associated DiseasesAls, Alzheimer
InteractionsAPOE, APP, CALB1, CCT4, COPA, IGF2R
KG Connections59 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Microbial Inflammasome Priming Prevention
Score: 0.65

Related Analyses (8)

Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (28)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40
Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Down Syndrome Alzheimer's Disease: Mechanisms and Therapeuti
clinical · proposed · Score: 0.40

See Also (11)

Genes
index · KG edge: associated_with
CALB1 (Calbindin 1)
gene · KG edge: associated_with
cct4
gene · KG edge: associated_with
PRDX3 — Peroxiredoxin 3
gene · KG edge: associated_with
RNF14 — Ring Finger Protein 14
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IDS associated_with SYNCRIP
IDS associated_with SSBP1
IDS associated_with PRDX3
IDS associated_with APP
IDS associated_with APOE
IDS associated_with SYNE2
IDS associated_with SMARCB1
IDS associated_with ULK2
IDS associated_with TMEM59
IDS associated_with SFPQ

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