gene 1,719 words KG: HNRNPK
Contents

HNRNPK Gene

🧬 Gene Info
Gene SymbolHNRNPK
Chromosome9q21.32
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight51 kDa
Exons17
PathwaysMAPK signaling, Wnt signaling
Ensembl IDENSG00000165119
GeneCardsHNRNPK
Human Protein AtlasHNRNPK
Pre-mRNA processingAlternative splicing regulation
mRNA stabilityBinds to AU-rich elements (AREs) in 3' UTRs
TranslationModulates translation initiation and elongation
Telomere maintenanceAssociates with telomeric DNA
MAPK signalingParticipates in ERK and p38 pathways
Wnt signalingRegulates β-catenin activity
Associated DiseasesAls
InteractionsATG, AUTOPHAGY, CALCOCO2, CKB, EGR1, IFN
KG Connections71 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

PARP1 Inhibition Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Nucleolar Stress Response Normalization
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: expressed_in
CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2
gene · KG edge: degrades
CKB Gene
gene · KG edge: interacts_with
EGR1 Gene
gene · KG edge: activates
HNRNPA1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PTBP1 expressed_in HNRNPK
TARDBP expressed_in HNRNPK
CALCOCO2 activates HNRNPK
EGR1 activates HNRNPK
HNRNPK activates NDP52
HNRNPK expressed_in HNRNPA1
HNRNPA1 expressed_in HNRNPK
NDP52 activates HNRNPK
HNRNPK activates EGR1
CALCOCO2 associated_with HNRNPK

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