gene 2,669 words KG: CALB1
Contents

CALB1 (Calbindin 1)

🧬 Gene Info
Gene SymbolCALB1
Chromosome8q21.3
Protein TypeGene
Functionis a gene located on chromosome 8q21.
Primary Expressionselect neuronal populations throughout the central and peripheral nervous systems, including cerebellar Purkinje cells, hippocampal interneurons and p
Subcellular Localizationand calcium-binding kinetics
Molecular Weight30 kDa
Amino Acids261 aa
Exons9
PathwaysMapk
UniProt IDP05937
NCBI Gene ID793
GeneCardsCALB1
Human Protein AtlasCALB1
Associated DiseasesAls, Alzheimer, Inflammation, Ms
InteractionsALZHEIMER, APOE, APP, ASTROCYTES, Bdnf, BDNF
KG Connections140 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Lysosomal Enzyme Trafficking Correction
Score: 0.71

Related Analyses (7)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (30)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.51
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40

See Also (15)

LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 10 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 10 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses

Knowledge Graph (12 edges)

CALB1 associated_with KCNN3
CALB1 associated_with GRIN2B
CALB1 associated_with CAV1
CALB1 associated_with GAIN
CALB1 associated_with CACNA1C
SLC17A7 biomarker_for CALB1
RAB7 expressed_in CALB1
AKT expressed_in CALB1
RAB5 expressed_in CALB1
CACNA1G biomarker_for CALB1

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