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gene 1,101 words KG: CCT4
Contents

CCT4 Gene

🧬 Gene Info
Gene SymbolCCT4
Full NameChaperonin Containing TCP1 Subunit 4 (Delta)
Chromosome2p15
Protein TypeChaperone
Molecular Weight58 kDa
Amino Acids539 aa
Exons12
UniProt IDP50991
NCBI Gene ID10382
Ensembl IDENSG00000108771
OMIM605588
GeneCardsCCT4
Human Protein AtlasCCT4
Associated DiseasesAls, Alzheimer
InteractionsALZHEIMER, APOE, APP, CALB1, COPA, IDS
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (19)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypothesesLX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypothesesUPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypothesesremternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

IDS associated_with CCT4
SYNCRIP associated_with CCT4
SSBP1 associated_with CCT4
PRDX3 associated_with CCT4
APP associated_with CCT4
APOE associated_with CCT4
SYNE2 associated_with CCT4
SMARCB1 associated_with CCT4
ULK2 associated_with CCT4
TMEM59 associated_with CCT4

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