gene 744 words KG: SAMHD1
Contents

SAMHD1 — SAM and HD Domain Containing Metal Dependent Hydrolase 1

🧬 Gene Info
Gene SymbolSAMHD1
Full NameSAM and HD Domain Containing Metal Dependent Hydrolase 1
Chromosome20q11.23
Protein TypeHydrolase
Functionis a gene located on chromosome 20q11.
Primary ExpressionUbiquitously expressed; high expression in brain, hematopoietic cells
Amino Acids626 aa
Exons20
PathwaysNf-Κb
UniProt IDQ9Y3D9
NCBI Gene ID9833
Ensembl IDENSG00000101347
OMIM606754
GeneCardsSAMHD1
Human Protein AtlasSAMHD1
Associated DiseasesAlzheimer, Amyotrophic Lateral Sclerosis
InteractionsATM, MRE11, MUTYH, NBS1, NEIL1, P53
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (14)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48

Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (15)

IKBKG Gene
gene · KG edge: regulates
OPTN — Optineurin
gene · KG edge: associated_with
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: expressed_in
CTC1 Gene
gene · KG edge: expressed_in
MRE11 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

SAMHD1 associated_with TREX1
SAMHD1 regulates IKBKG
SAMHD1 associated_with PSMB8
TREX1 interacts_with SAMHD1
VCP interacts_with SAMHD1
NEIL1 interacts_with SAMHD1
POLD1 expressed_in SAMHD1
POT1 interacts_with SAMHD1
MRE11 interacts_with SAMHD1
MUTYH interacts_with SAMHD1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)