| Gene Symbol | NBS1 |
| Full Name | Nijmegen Breakage Syndrome 1 / Nibrin |
| Aliases | Nibrin |
| Chromosome | 8q21.3. |
| Function | is a critical DNA repair protein that plays a central role in maintaining genomic stability. |
| Amino Acids | 754 aa |
| UniProt ID | [O60347](https://www.uniprot.org/uniprot/O60347) |
| Ensembl ID | ENSG00000104320 |
| GeneCards | NBS1 |
| Human Protein Atlas | NBS1 |
| RAD50 | A protein that bridges DNA ends and maintains DNA end proximity |
| NBS1 | The signaling and scaffolding component |
| Oxidative stress | ROS-induced base modifications and single-strand breaks |
| Endogenous metabolic byproducts | Spontaneous depurination, deamination reactions |
| Transcriptional stress | RNA polymerase stalling and transcription-coupled repair deficits |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | ATM, CANCER, COMPLEMENT, CTC1, DNA, IR |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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