| Gene Symbol | POLD1 |
| Chromosome | 19q13.3 |
| Protein Family | DNA polymerase delta family |
| Function | The enzyme exhibits lower processivity compared to Pol ε (the leading strand polymerase) but achieves high fidelity through its intrinsic 3'→5' exonuclease proofreading activity[@burgers2019]. |
| Subcellular Localization | Nucleus |
| Molecular Weight | 124 kDa |
| UniProt ID | [P28340](https://www.uniprot.org/uniprot/P28340) |
| GeneCards | POLD1 |
| Human Protein Atlas | POLD1 |
| POLD1 (p125) | Catalytic subunit with polymerase and proofreading activities |
| POLD2 (p50) | Regulatory subunit, essential for complex stability |
| POLD3 (p66) | Accessory subunit, involved in subcellular localization |
| Associated Diseases | neurodegeneration |
| Interactions | ATM, MRE11, MUTYH, NBS1, NEIL1, P53 |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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