| Gene Symbol | ARF1 |
| Protein Family | ARF GTPase family |
| Function | is a small GTP-binding protein that functions as a molecular switch regulating vesicle trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. |
| Subcellular Localization | Golgi apparatus, ER-Golgi intermediate compartment |
| Molecular Weight | 20.7 kDa |
| Amino Acids | 181 aa |
| UniProt ID | [P84077](https://www.uniprot.org/uniprot/P84077) |
| GeneCards | ARF1 |
| Human Protein Atlas | ARF1 |
| GTP-binding domain | Switch between active (GTP-bound) and inactive (GDP-bound) states |
| N-terminal myristoylation | Lipid modification for membrane association |
| Switch I and II regions | Conformational changes upon GTP/GDP binding |
| Effector loop | Mediates interactions with downstream targets |
| ArfGAP domain | GTPase-activating protein binding site |
| ER-Golgi transport | Regulates COP I vesicle formation |
| Associated Diseases | neurodegeneration |
| Interactions | Actin, AND, ASTROCYTE, ASTROCYTES, CANCER, Fus |
| KG Connections | 74 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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