Contents

EPHB4 Gene

🧬 Gene Info

Gene Symbol	Eph Receptor B4
Chromosome	5q22.1
Protein Type	Kinase
Target Class	Kinase
Function	Small molecule inhibitor of receptor tyrosine kinase activity
Mechanism of Action	Small molecule inhibitor of receptor tyrosine kinase activity
Primary Expression	the ventricular zone and cortical plate, coinciding with periods of active neurogenesis and neuronal migration
Druggability	Low (0.43)
Clinical Stage	Approved
Pathways	Ephrin-EphB receptor signaling
UniProt ID	Q541P7
NCBI Gene ID	2050
Ensembl ID	ENSG00000196411
OMIM	600010
Cerebral cortex	High expression in layer V pyramidal neurons, particularly in prefrontal and parietal cortices
Associated Diseases	AD, ALI, Als, cancer
Known Drugs/Compounds	Icariin
Interactions	ADAM17, AKT, AND, ANGPTL4, APOE, App
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	Ephrin-B2/EphB4 Axis Manipulation
KG Connections	174 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph