gene 702 words KG: REL
Contents

REL Gene

🧬 Gene Info
Gene SymbolREL
Full Namec-Rel Proto-Oncogene, NF-Kappa B Subunit
Chromosome2p16.1
FunctionREL (c-Rel) is a member of the NF-κB family that forms heterodimers with p50 and p52.
Primary Expressionhematopoietic cells, with lower expression in other tissues
PathwaysAkt, Apoptosis, Complement, Immune Response, Lipid Metabolism
UniProt IDP41160
NCBI Gene ID5966
Ensembl IDENSG00000162924
OMIM164913
GeneCardsREL
Human Protein AtlasREL
Associated DiseasesAD, Aging, ALI, Als, AMI, disease
InteractionsAND, APOPTOSIS, BCL2L1, CANCER, CYTOKINES, FOXO1
KG Connections152 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74

Related Analyses (10)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

REL transcription factor mediates VLC ceramide-driven inflam
exploratory · proposed · Score: 0.75

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: activates
HDAC6 (Redirect)
redirect · KG edge: regulates
BCL2L1 Gene
gene · KG edge: activates
CD4 Gene
gene · KG edge: regulates
cdkn2a
gene · KG edge: regulates

Knowledge Graph (12 edges)

CERS2 regulates REL
CERS2 associated_with REL
REL implicated_in inflammatory bowel disease
CDKN2A regulates REL
TP53 regulates REL
TET2 expressed_in REL
MYD88 expressed_in REL
KMT2D expressed_in REL
STAT3 regulates REL
DDX3X expressed_in REL

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