| Gene Symbol | RB1 |
| Full Name | Retinoblastoma 1 |
| Chromosome | 13q14.2 |
| Function | is a critical tumor suppressor gene with important functions in the nervous system. |
| Pathways | Akt, Apoptosis, Autophagy, Dna Methylation, E2F pathway |
| UniProt ID | P06400 |
| NCBI Gene ID | 5925 |
| Ensembl ID | ENSG00000139687 |
| OMIM | 180200 |
| GeneCards | RB1 |
| Human Protein Atlas | RB1 |
| N-terminal domain | Involved in protein-protein interactions |
| Pocket domain | Binds E2F transcription factors; target for viral oncoproteins |
| C-terminal domain | Regulates pocket function and protein stability |
| Cell cycle regulation | Controls neuronal cell cycle exit during development[@liu2019] |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | ABCD3, ACAT1, ACHE, ACSL4, Actin, AD |
| KG Connections | 1624 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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