| Gene Symbol | PRKACA |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 40.6 kDa |
| Pathways | mTOR, mtor |
| GeneCards | PRKACA |
| Human Protein Atlas | PRKACA |
| Serine/threonine kinase | Phosphorylates serine and threonine residues |
| cAMP-dependent | Activity requires binding of cAMP to regulatory subunits |
| Heterotetrameric complex | R2C2 (2 regulatory + 2 catalytic subunits) |
| Substrate specificity | Broad substrate range including transcription factors, ion channels, and metabolic enzymes |
| Catalytic domain | Kinase domain in the C-terminal region |
| Nuclear localization | Can translocate to nucleus to phosphorylate transcription factors |
| Isoforms | Multiple catalytic subunit isoforms (Cα, Cβ, Cγ) |
| Autophosphorylation | Regulatory serine residues |
| Brain | High expression in hippocampus, cortex, cerebellum |
| Associated Diseases | Infection, Inflammation, Sepsis |
| Interactions | Actin, AND, CAV1, CAVEOLIN-1, CPT1A, Ras |
| KG Connections | 85 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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