gene 797 words KG: CHMP7
Contents

CHMP7 mutations cause hereditary spastic paraplegia

🧬 Gene Info
Gene SymbolCHMP7
Full NameCharged Multivesicular Body Protein 7
Chromosome8p21.3
Functionis a unique hybrid ESCRT-III/CHMP4 family member with distinct functions in both the endosomal system and nuclear envelope maintenance.
PathwaysCRISPR-Cas, oxidative stress response
UniProt ID[Q9Y3X5](https://www.uniprot.org/uniprot/Q9Y3X5)
Ensembl IDENSG00000165457
GeneCardsCHMP7
Human Protein AtlasCHMP7
Associated DiseasesALS, Infection, Inflammation, Sepsis
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, CHMP2B, CHMP4B
KG Connections104 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
CD4 Gene
gene · KG edge: associated_with
CD8 Gene
gene · KG edge: associated_with
CHMP2B — Charged Multivesicular Body Protein 2B
gene · KG edge: activates

Knowledge Graph (12 edges)

CHMP7 activates CHMP2B
HTRA2 associated_with CHMP7
AIM2 associated_with CHMP7
GBM associated_with CHMP7
CHMP7 associated_with CD8
CHMP7 associated_with MAP1LC3B
CHMP7 associated_with PRKACA
CHMP7 associated_with NLRC4
CHMP7 associated_with CD4
CHMP7 associated_with GCLM

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