Validation experiment designed to validate causal mechanisms targeting NTN1 in Primary mouse model. Primary outcome: Netrin-1 expression levels in SCC
This experiment examined netrin-1 expression patterns in a primary mouse model of skin squamous cell carcinoma (SCC) that exhibits spontaneous epithelial-to-mesenchymal transition (EMT). The researchers used this model to investigate the role of netrin-1 in cancer progression and EMT regulation. The study found that netrin-1 was upregulated in the SCC model, suggesting its potential involvement in EMT processes and cancer progression.
Primary mouse model of skin SCC with analysis of netrin-1 expression patterns
Upregulation of netrin-1 in SCC exhibiting spontaneous EMT
Detection of increased netrin-1 expression in EMT-positive tumors
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