gene 1,156 words KG: CERS6
Contents

CERS6 Gene

🧬 Gene Info
Gene SymbolCERS6
Full NameCeramide Synthase 6
Chromosome2q33.3
Protein TypeSynthase
Functionencodes a member of the ceramide synthase family that catalyzes the N-acylation of sphingoid bases to produce ceramides.
Primary ExpressionEndoplasmic reticulum membrane, where de novo ceramide synthesis occurs
Subcellular LocalizationEndoplasmic reticulum membrane, where de novo ceramide synthesis occurs
Molecular Weight45 kDa
Amino Acids384 aa
PathwaysCeramide Metabolism
UniProt IDQ3YGD3
NCBI Gene ID253782
Ensembl IDENSG00000166922
OMIM615990
GeneCardsCERS6
Human Protein AtlasCERS6
Associated Diseasesneurodegeneration
InteractionsAGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS, APP
KG Connections78 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (7)

Sphingolipid Metabolism Reprogramming
Score: 0.62
CYP46A1 Overexpression Gene Therapy
Score: 0.98
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: debate_co_mention
ASAH1 — N-Acylsphingosine Amidohydrolase 1
gene · KG edge: activates
BCL2 Gene
gene · KG edge: interacts_with
BCL2L13
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CERS6 expressed_in WIPI2
GBM therapeutic_target CERS6
BCL2 interacts_with CERS6
BCL2L13 interacts_with CERS6
CERS6 interacts_with CERS2
CERS6 interacts_with APP
CERS6 inhibits PARKIN
SGMS2 activates CERS6
CERS6 activates ASAH1
CERS6 activates CERS2

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