gene 1,538 words KG: NGF
Contents

NGF Gene

🧬 Gene Info
Gene SymbolNGF
Full NameNerve Growth Factor
Chromosome1p13.1
Protein FamilyNeurotrophin family
Primary ExpressionPrimarily in nociceptive sensory neurons, cholinergic basal forebrain neurons, sympathetic ganglia
Molecular Weight30 kDa
Amino Acids120 aa
Exons3
PathwaysPI3K, MAPK
UniProt IDP01138
NCBI Gene ID4800
Ensembl IDENSG00000111665
OMIM162030
GeneCardsNGF
Human Protein AtlasNGF
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, ANGIOGENESIS
Known Drugs/Compoundsaducanumab, lecanemab, metformin
InteractionsACHE, Actin, ADRB2, AGING, Akt, AKT
KG Connections762 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (30)

Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
← Prevpg 2/2

Related Analyses (11)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (4)

ABCA7 (Redirect)
redirect · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits

Knowledge Graph (12 edges)

NGF activates CHR2
NGF activates BDNF
TRKA interacts_with NGF
NRP1 activates NGF
NGF inhibits GAIN
NGF activates DCX
NGF expressed_in BDNF
NGF activates HES1
NGF activates NESTIN
NGF activates NOTCH1

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