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gene 1,687 words KG: A2M
Contents

A2M Gene

🧬 Gene Info
Gene SymbolA2M
Chromosome12p13.31 (human)
Protein Familyα2-macroglobulin family
FunctionThe protein possesses a unique "trap" mechanism
Molecular Weight~720 kDa (tetramer)
Amino Acids1450 amino acids
UniProt IDP01023
NCBI Gene ID2
GeneCardsA2M
Human Protein AtlasA2M
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI, Depression
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APH1B, APOE
KG Connections107 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (25)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Glycosaminoglycan Template Disruption Approach
Score: 0.60TREM2-Dependent Microglial Senescence Transition
Score: 0.95

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_withAccelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_inAPH1B Gene - Anterior Pharynx Defective 1 Homolog B
gene · KG edge: interacts_withAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_withPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

NCSTN interacts_with A2M
FAS interacts_with A2M
TNF interacts_with A2M
LMNA interacts_with A2M
APH1B interacts_with A2M
APOE interacts_with A2M
IL6 interacts_with A2M
SREBF1 interacts_with A2M
PSEN2 interacts_with A2M
A2M interacts_with DHCR24

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