| Gene Symbol | HSF1 |
| Aliases | Page for HSF1 Gene, Page for HSF1 Protein |
| Function | HSF1 functions as a DNA-binding transcription factor that activates heat shock gene expression in response to various cellular stresses including heat, oxidative stress, and proteotoxic stress. |
| Primary Expression | cancers and promotes tumor survival through enhanced proteostasis and metabolic adaptation |
| Molecular Weight | 53 kDa |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000185122 |
| GeneCards | HSF1 |
| Human Protein Atlas | HSF1 |
| Associated Diseases | Cancer, Dementia, disease, Huntington, Huntington's disease, Neurodegeneration |
| Known Drugs/Compounds | DH1, M102 |
| Interactions | AKT, ALS, AND, APOPTOSIS, AUTOPHAGY, Bdnf |
| SciDEX Hypotheses | HSF1 reprioritizes transcription and suppresses MA |
| KG Connections | 237 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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