gene 879 words KG: H2AX
Contents

H2AX Gene

🧬 Gene Info
Gene SymbolH2AX
Chromosome11q23.2
FunctionH2AX is a variant histone that comprises ~2-10% of the H2A pool in mammalian cells.
PathwaysApoptosis, Proteasome, Ubiquitin-Proteasome
UniProt IDP16104
NCBI Gene ID3014
GeneCardsH2AX
Human Protein AtlasH2AX
Associated DiseasesAls, neurodegeneration, Parkinson, Senescence
InteractionsACTB, AGING, Alpha-Synuclein, AND, APOPTOSIS, AR
KG Connections293 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (13)

PARP1 Inhibition Therapy
Score: 0.74
R-Loop Resolution Enhancement Therapy
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ACTB Gene
gene · KG edge: associated_with
ar
gene · KG edge: activates
ATG14 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ACTB associated_with H2AX
CDC42 associated_with H2AX
CASP3 associated_with H2AX
SQSTM1 regulates H2AX
TUBB3 regulates H2AX
STK11 regulates H2AX
VIM regulates H2AX
BECN1 associated_with H2AX
HDAC6 regulates H2AX
GAPDH associated_with H2AX

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