gene 2,140 words KG: GNG2
Contents

GNG2 Gene

🧬 Gene Info
Gene SymbolGNG2
Full NameG protein subunit gamma 2
Chromosome14q21.3
Protein FamilyG protein gamma subunit family
Functionencodes a critical component of heterotrimeric G proteins that mediate cellular signaling throughout the nervous system.
Molecular Weight7.6 kDa
Amino Acids71 aa
Exons4
PathwaysPI3K
UniProt ID[P59768](https://www.uniprot.org/uniprot/P59768)
Ensembl IDENSG00000186472
OMIM606314
GeneCardsGNG2
Human Protein AtlasGNG2
C-terminal CAAX motifCys-aliphatic-aliphatic-X sequence (Cys-Val-Ile-Ile in Gγ2)
Associated Diseasesneurodegeneration
InteractionsAKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, GNAI1
KG Connections23 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
AKT1 Gene
gene · KG edge: interacts_with
AMPD2 — Adenosine Monophosphate Deaminase 2
gene · KG edge: expressed_in
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

GNAI1 interacts_with GNG2
AKT1 interacts_with GNG2
AKT interacts_with GNG2
GNB1 interacts_with GNG2
AMPD2 expressed_in GNG2
ATG5 interacts_with GNG2
MAVS interacts_with GNG2
TBK1 interacts_with GNG2
CLCN7 expressed_in GNG2
RIPK2 interacts_with GNG2

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