| Gene Symbol | NOD2 |
| Function | NOD2 encodes nucleotide-binding oligomerization domain-containing protein 2, an intracellular pattern recognition receptor that senses bacterial muramyl dipeptide (MDP). |
| Primary Expression | the brain and may contribute to neurodegeneration: |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000105904 |
| GeneCards | NOD2 |
| Human Protein Atlas | NOD2 |
| Innate immune sensing | Recognizes bacterial components and initiates inflammatory responses |
| [NF-κB](/entities/nf-kb) activation | Triggers pro-inflammatory signaling cascades |
| Mucosal defense | Critical for intestinal barrier function |
| Anti-microbial peptides | Induces alpha-defensin production in Paneth cells |
| Associated Diseases | Als, Atherosclerosis, Cancer, Colorectal Cancer, Crohn's disease, IBD |
| Known Drugs/Compounds | rapamycin |
| Interactions | Actin, AKT, AKT1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE |
| KG Connections | 318 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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