| Gene Symbol | GNAS |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | endocrine tissues, heart, kidney |
| Pathways | MAPK pathway |
| GeneCards | GNAS |
| Human Protein Atlas | GNAS |
| Adenylyl cyclase activation | Stimulates cAMP production |
| GTP binding and hydrolysis | Classic G protein cycle |
| Effector pathways | Activates adenylyl cyclase isoforms I-IX |
| Alternative splicing | Multiple splice variants with distinct functions |
| Stimulatory signaling | Gs proteins promote cAMP formation |
| Isoform diversity | Gαs, Gαs-L, Gαolf, GαsXL |
| Imprinting | GNAS is imprinted in a tissue-specific manner |
| Second messenger system | cAMP is the primary second messenger |
| Brain | Widespread expression throughout the CNS |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, BNIP3L |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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