gene 585 words KG: GAIN
Contents

GAIN Gene - GABA-A Receptor Associated Protein Like 2

🧬 Gene Info
Gene SymbolGAIN
Full NameGAIN - GABA-A Receptor Associated Protein Like 2
AliasesPage for GAIN Gene, GABARAPL2
Chromosome16p13.3
Protein TypeGene
Functionencodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expressionvarious tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID124454
GeneCardsGAIN
Human Protein AtlasGAIN
Associated Diseasesaging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsACAT1, ACC, ACHE, Actin, AGING, AIF
KG Connections1870 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (158)

Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Glycosaminoglycan Template Disruption Approach
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
← Prevpg 7/8Next →

Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (9)

acc-chronic-pain
cell_type · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ABCG1 Gene
gene · KG edge: expressed_in
ADRB2 Gene
gene · KG edge: causes
AIF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TIGAR activates GAIN
IDH2 activates GAIN
GAIN activates TKT
TMEM119 biomarker_for GAIN
P2RY12 biomarker_for GAIN
GAIN biomarker_for TREM2
GAIN inhibits GABRA1
GABRA1 associated_with GAIN
GAIN associated_with DLK1
VCP activates GAIN

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.