gene 585 words KG: GAIN
Contents

GAIN Gene - GABA-A Receptor Associated Protein Like 2

🧬 Gene Info
Gene SymbolGAIN
Full NameGAIN - GABA-A Receptor Associated Protein Like 2
AliasesPage for GAIN Gene, GABARAPL2
Chromosome16p13.3
Protein TypeGene
Functionencodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expressionvarious tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID124454
GeneCardsGAIN
Human Protein AtlasGAIN
Associated Diseasesaging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
InteractionsACAT1, ACC, ACHE, Actin, AGING, AIF
KG Connections1870 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (158)

Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Cryptic Exon Silencing Restoration
Score: 0.53
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
← Prevpg 8/8

Related Analyses (30)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (9)

acc-chronic-pain
cell_type · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ABCG1 Gene
gene · KG edge: expressed_in
ADRB2 Gene
gene · KG edge: causes
AIF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TIGAR activates GAIN
IDH2 activates GAIN
GAIN activates TKT
TMEM119 biomarker_for GAIN
P2RY12 biomarker_for GAIN
GAIN biomarker_for TREM2
GAIN inhibits GABRA1
GABRA1 associated_with GAIN
GAIN associated_with DLK1
VCP activates GAIN

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