gene 646 words KG: DNM1L
Contents

DNM1L Gene

🧬 Gene Info
Gene SymbolDNM1L
Full NameDynamin 1 Like (Dynamin-Related Protein 1)
Chromosome12p11.21
FunctionDRP1 orchestrates mitochondrial fission
Primary Expressionastrocytes and microglia
PathwaysApoptosis, Mitochondrial Function, Mitophagy, Oxidative Stress
UniProt ID[O00429](https://www.uniprot.org/uniprot/O00429)
Ensembl IDENSG00000087470
GeneCardsDNM1L
Human Protein AtlasDNM1L
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsmetformin, rapamycin
InteractionsABCD3, ADORA2A, AIF1, AKT, ALS, ALZHEIMER
KG Connections965 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
← Prevpg 2/2

Related Analyses (9)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ADORA2A Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with DNM1L
OPTN interacts_with DNM1L
DNM1L interacts_with CANX
DNM1L interacts_with LGALS3
DNM1L interacts_with CALCOCO2
DNM1L interacts_with G3BP1
DNM1L interacts_with PEX3
DNM1L interacts_with SQSTM1
DNM1L interacts_with BCL2
DNM1L interacts_with LMNA

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