| Gene Symbol | CDK5 |
| Protein Family | CMGC kinase group, CDK family |
| Protein Type | Serine/Threonine Kinase |
| Function | Cdk5 knockout mice die at birth with severe cortical layering defects due to failed neuronal migration. |
| Primary Expression | Cytoplasm, nucleus, synapses, growth cones, perinuclear region |
| Amino Acids | 291 aa |
| Pathways | Apoptosis, Autophagy, Checkpoint Inhibitor, Immune Checkpoint, Immune Response |
| GeneCards | CDK5 |
| Human Protein Atlas | CDK5 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Ataxia |
| Known Drugs/Compounds | metformin, METFORMIN, N-ACETYLCYSTEINE, Protopanaxatriol, RESVERATROL |
| Interactions | ABETA, ACHE, Actin, AD, AGING, AKT |
| SciDEX Hypotheses | CDK5 Inhibition at Presynaptic Terminals Prevents CDK5 Inhibition Blocks Activity-Dependent Tau Prop |
| KG Connections | 772 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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