gene 606 words KG: CALCOCO2
Contents

CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2

🧬 Gene Info
Gene SymbolCALCOCO2
Full NameCalcium Binding and Coiled-Coil Domain 2
Chromosome17q25.1
Protein TypeReceptor
FunctionXenophagy: Recognition and elimination of intracellular pathogens including bacteria, viruses, and parasites
Molecular Weight52 kDa
Amino Acids446 aa
PathwaysAkt, Autophagy, Mapk, Mitophagy, Mtor
UniProt ID[Q9BQB6](https://www.uniprot.org/uniprot/Q9BQB6)
Ensembl IDENSG00000136436
OMIM604551
GeneCardsCALCOCO2
Human Protein AtlasCALCOCO2
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Cardiac, Crohn's disease
Known Drugs/Compoundsdimethyl fumarate, rapamycin
InteractionsABCD3, ABP, ACAT1, ACTB, Actin, AIFM1
KG Connections1119 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
← Prevpg 2/2

Related Analyses (12)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (3)

Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: regulates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PEDV_N_protein interacts_with CALCOCO2
ACTB interacts_with CALCOCO2
OPTN interacts_with CALCOCO2
ULK1 interacts_with CALCOCO2
SMCR8 interacts_with CALCOCO2
CALCOCO2 interacts_with LC3
CALCOCO2 interacts_with BECN1
CALCOCO2 interacts_with C9ORF72
CALCOCO2 interacts_with NBR1
CALCOCO2 interacts_with G3BP1

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