| Gene Symbol | SNAP |
| Aliases | SNAP25 |
| Chromosome | 20p12 |
| Target Class | Structural Protein |
| Function | Snap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Mechanism of Action | Protein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation |
| Druggability | Low (0.33) |
| Clinical Stage | Approved |
| GeneCards | SNAP |
| Human Protein Atlas | SNAP |
| N-terminal region | Contains palmitoylation sites for membrane attachment |
| SNARE motif (Habc domain) | Forms coiled-coil structure with syntaxin-1 and VAMP2 |
| C-terminal region | Two SNARE motifs (SN1 and SN2) separated by a 9-residue linker |
| SNAP-25 | Provides two alpha-helical SNARE motifs |
| Syntaxin-1 | Membrane-bound Q-SNARE on presynaptic plasma membrane |
| Associated Diseases | Als, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | ACTB, ACTG1, Actin, AD, AKT, ALZHEIMER |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | Targeting Synaptic Vesicle Release Machinery to Bl Synaptic Vesicle Tau Capture Inhibition Synaptic Vesicle Tau Capture Inhibition |
| KG Connections | 656 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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