| Gene Symbol | SNAP |
| Full Name | 25 (Synaptosomal-Associated Protein 25) |
| Aliases | SNAP25 |
| Chromosome | 20p12.2 |
| Target Class | Structural Protein |
| Function | Snap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Mechanism of Action | Protein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation |
| Druggability | Low (0.33) |
| Clinical Stage | Approved |
| GeneCards | SNAP |
| Human Protein Atlas | SNAP |
| Lewy Body Dementia | Elevated CSF SNAP-25 |
| Frontotemporal Dementia | Variable changes |
| Amyotrophic Lateral Sclerosis | May reflect motor neuron synaptic loss |
| Associated Diseases | Als, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | ACTB, ACTG1, Actin, AD, AKT, ALZHEIMER |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | Targeting Synaptic Vesicle Release Machinery to Bl Synaptic Vesicle Tau Capture Inhibition Synaptic Vesicle Tau Capture Inhibition |
| KG Connections | 655 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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