Contents

A/T/N+ Comprehensive Biomarker Panel for Alzheimer's Disease Staging

🔬 Protein Info

Gene Symbol	AD
Blood-based panel (6 markers)	Aβ42/Aβ40, p-Tau217, p-Tau231, NfL, GFAP, sTREM2
CSF panel (8 markers)	All above plus neurogranin and SNAP-25
Optimal approach	Blood for screening, CSF for confirmation and staging
Associated Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, CORTICOBASAL DEGENERATION, CREUTZFELDT-JAKOB, DEMENTIA, FRONTOTEMPORAL DEMENTIA
Known Drugs/Compounds	HTL9936, resveratrol
Interactions	AB, ABCA1, ACHE, ADAM10, ADAM17, AIF1
SciDEX Hypotheses	Stratified falsifiers should govern AD Master Plan Stratified falsifiers should govern AD Master Plan Stratified falsifiers should govern AD Master Plan (+2 more)
KG Connections	1501 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

GSS implicated_in AD

CYP2E1 implicated_in AD

IDH2 implicated_in AD

IDH1 implicated_in AD

VEGFA implicated_in AD

EEF1A1 implicated_in AD

APOB implicated_in AD

MET implicated_in AD

MCL1 implicated_in AD

SF3B1 implicated_in AD