| Gene Symbol | DTI |
| Principle | Water diffusion is restricted by cellular structures |
| Key metrics | Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD) |
| Advantage | Detects white matter abnormalities before macroscopic atrophy |
| Clinical utility | Early detection, disease progression, differential diagnosis |
| Definition | Average of second and third eigenvalues |
| Normal range | 0.7-0.9 × 10⁻³ mm²/s in white matter |
| AD changes | Often increases in demyelination |
| Interpretation | Reflects myelin integrity |
| Finding | Most sensitive to early AD changes |
| Significance | Default mode network disruption |
| Early marker | Sensitive to early AD changes |
| Clinical correlation | Correlates with episodic memory deficits |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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