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biomarker 1,137 words KG: ALZHEIMERS
Contents

Ocular Fluid Biomarkers for Alzheimer's Disease

🔬 Protein Info
Gene Symbolalzheimers
Aliasesalzheimers
Aqueous humorClear fluid in the anterior chamber (between cornea and lens)
Vitreous humorGel-like substance filling the posterior chamber (behind lens, before retina)
AD finding1.8-2.5 fold increase
Sensitivity70-78%
Specificity68-75%
CorrelationCorrelates with cognitive decline (MMSE r=-0.58)
NoteLess AD-specific than p-Tau, elevated in other neurodegenerative conditions
Associated DiseasesALZHEIMER
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (29)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76

Related Analyses (19)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedCell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (30)

Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesAstrocyte-Derived Exosomal mRNA Reference Genes for Alz
biomarker · Pages share 18 hypothesesAT(N) Biomarker Classification for Alzheimer's Disease
biomarker · Pages share 18 hypothesesA/T/N+ Comprehensive Biomarker Panel for Alzheimer's Di
biomarker · Pages share 18 hypothesesBlood p-Tau217 as a Clock for Alzheimer's Disease Onset
mechanism · Pages share 18 hypotheses

Knowledge Graph (6 edges)

TREM2 associated_with ALZHEIMERS
SERPINA3N associated_with ALZHEIMERS
ALZHEIMERS activates WAM
R47H_TREM2 contributes_to ALZHEIMERS
DAM associated_with ALZHEIMERS
MICROGLIA participates_in ALZHEIMERS

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