CHRNA7

CHRNA7 Protein

Score: 0.387 Price: $0.39 Undruggable Druggability Status: active Wiki: CHRNA7 Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 CHRNA7 — PDB 7EKK Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: P36544

🧬 3D Protein Structure

🧬 CHRNA7 — PDB 7EKK Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for P36544

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Linked Hypotheses (2)

Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication0.669

Cholinergic Attention Modulation Hypothesis0.528

Linked Experiments (3)

HFD-induced cognitive dysfunction and neuroinflammation in mice0.900

α7nAChR agonist treatment rescues HFD-induced memory deficits0.850

α7nAChR knockout mice show enhanced HFD sensitivity0.800

Scoring Dimensions

Knowledge Graph (20)

regulates (20)

PANX1→CHRNA7S100B→CHRNA7RELB→CHRNA7P2RY1→CHRNA7CASP3→CHRNA7

▸ Show 15 more

SOCS3→CHRNA7TRPA1→CHRNA7CXCL2→CHRNA7SNAP25→CHRNA7P2RX7→CHRNA7SYT2→CHRNA7TNF→CHRNA7SOD2→CHRNA7NOS2→CHRNA7P2RX3→CHRNA7RELA→CHRNA7SYP→CHRNA7CHRNA7→SYT1CHRNA7→STAT3CHRNA7→HMOX1

Debate History (1)

Should CHRNA7 (CHRNA7 Protein) be prioritized as a therapeutic target for neurod2026-04-22