protein

LXR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LXR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

9Hypotheses

0Analyses

50Outgoing

45Incoming

0Experiments

0Debates

Summary

Page for LXR Protein (Liver X Receptor)

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🔬 Protein Info

Gene Symbol	LXR
Aliases	Liver X Receptor
Pathways	NF-κB
GeneCards	LXR
Human Protein Atlas	LXR
Associated Diseases	ALS, Alzheimer, glioblastoma, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ABCA1, ABCA7, ABCG1, ACAT1, AKT, AMPK
SciDEX Hypotheses	Upstream restoration of glial lipid efflux and apo
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    LXR(["LXR"])
    CD38(["CD38"])
    S1PR1["S1PR1"]
    Kupffer_Cell_Survival("Kupffer Cell Survival")
    Cholesterol_Efflux("Cholesterol Efflux")
    S1P1["S1P1"]
    AP_1(["AP-1"])
    SREBP1["SREBP1"]
    Metabolic_Stress("Metabolic Stress")
    KUPFFER_CELLS["KUPFFER_CELLS"]

    LXR -->|"upregulates"| CD38
    S1PR1 -->|"activates"| LXR
    LXR -->|"regulates"| Kupffer_Cell_Survival
    LXR -->|"regulates"| Cholesterol_Efflux
    S1P1 -->|"upregulates"| LXR
    AP_1 -->|"modulates"| LXR
    LXR -->|"regulates"| SREBP1
    Metabolic_Stress -->|"activates"| LXR
    LXR -->|"regulates"| KUPFFER_CELLS

    style LXR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (59)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
Cholesterol Efflux	regulates	process	0.85
Kupffer Cell Survival	regulates	process	0.85
cholesterol homeostasis	participates_in	pathway	0.85
TAU	regulates	protein	0.80
APOE4	regulates	protein	0.80
SREBP1	regulates	entity	0.80
unfolded protein response	participates_in	pathway	0.75
lipid metabolism	participates_in	pathway	0.70
neuroinflammation	activates	disease	0.65
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	inhibits	disease	0.60
neurodegeneration	inhibits	disease	0.60
MAF	activates	gene	0.60
cardiovascular disease	activates	disease	0.60
T cells	expressed_in	cell_type	0.60
TREM2	inhibits	gene	0.60
neurodegeneration	protects_against	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
TNF	expressed_in	gene	0.60
PPAR	regulates	gene	0.60
cardiovascular disease	regulates	disease	0.60
Alzheimer's disease	activates	disease	0.60
Alzheimer's disease	expressed_in	disease	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
multiple sclerosis	activates	disease	0.60
MAPK	activates	gene	0.60
PKA	activates	gene	0.60
PI3K	activates	gene	0.60
neurodegeneration	regulates	disease	0.60
NLRP3	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
PPAR	activates	gene	0.60
neurodegeneration	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
RNA	inhibits	gene	0.60
glioblastoma	inhibits	disease	0.60
glioblastoma	associated_with	disease	0.60
KUPFFER_CELLS	regulates	cell_type	0.56
macrophages	expressed_in	cell_type	0.55
TREM2	protects_against	gene	0.55
SGMS1	expressed_in	gene	0.55
TREM2	associated_with	gene	0.55

Incoming (45)

Source	Relation	Type	Str
29563219	regulates transcription of	paper	0.90
AP-1	modulates	protein	0.85
S1P1	upregulates	receptor	0.85
APOE	expressed_in	gene	0.70
ATP	activates	gene	0.70
ABCA1	activates	gene	0.65
CYP46A1	activates	gene	0.65
APOE	associated_with	gene	0.65
ACAT1	activates	gene	0.60
APP	expressed_in	gene	0.60
APOE4	activates	gene	0.60
APOE	regulates	gene	0.60
AQP4	regulates	gene	0.60
ABCA1	inhibits	gene	0.60
IRF8	activates	gene	0.60
AKT	activates	gene	0.60
AMPK	activates	gene	0.60
rapamycin	targets	drug	0.60
LDL	activates	gene	0.60
ABCA1	associated_with	gene	0.60
LRP1	activates	gene	0.60
GBM	inhibits	gene	0.60
ACAT1	inhibits	gene	0.60
GAS6	regulates	gene	0.60
ABCA1	regulates	gene	0.60
ABCA7	regulates	gene	0.60
ABCG1	regulates	gene	0.60
ABCA1	expressed_in	gene	0.60
ABCA7	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
GAS6	expressed_in	gene	0.60
ABCA7	activates	gene	0.60
ABCG1	activates	gene	0.60
GAS6	activates	gene	0.60
APOE	protects_against	gene	0.55
APOE	activates	gene	0.55
APP	activates	gene	0.55
DGAT1	activates	gene	0.55
GBM	co_expressed_with	gene	0.50
HMGCR	co_expressed_with	gene	0.50
LDLR	co_expressed_with	gene	0.50
CYP46A1	co_expressed_with	gene	0.50
APOE3	co_expressed_with	protein	0.50
APOE4	co_expressed_with	gene	0.50
ABCA7	co_expressed_with	gene	0.50

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A	0.728	neuroscience	APOE4-driven lipid metabolism dysregulat
LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-	0.721	neurodegeneration	What specific molecular mechanisms link
LXRβ-Selective Agonism to Simultaneously Enhance APOE Lipida	0.668	lipidomics	Lipid metabolism dysregulation in Alzhei
Upstream restoration of glial lipid efflux and apoE lipidati	0.584	molecular biology	Does APOE4's reduced lipid-binding direc
LXR Agonism (H4): Microglial Lipid Efflux Promotion	0.580	neurodegeneration	Does restoring neuronal AMPK activity re

LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei
LXRα-Selective Agonism to Enhance Hepatic APOE Secretion and	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei
ABCA1 Upregulation via LXRβ Agonism to Enhance Cholesterol E	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei
CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lip	0.000	lipidomics	Lipid metabolism dysregulation in Alzhei

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LXR in their description or question text

LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide Generation to Restor

Score: 0.000 · lipidomics · 2026-04-27

This hypothesis proposes that LXRβ-selective agonists enhance CYP2J2 expression and activity to increase protective DHA

LXRα-Selective Agonism to Enhance Hepatic APOE Secretion and Peripheral Choleste

Score: 0.000 · lipidomics · 2026-04-27

This hypothesis proposes that selective activation of LXRα (NR1H3) represents a superior therapeutic approach for addres

ABCA1 Upregulation via LXRβ Agonism to Enhance Cholesterol Efflux and Prevent Ne

Score: 0.000 · lipidomics · 2026-04-26

This hypothesis proposes that selective LXRβ agonism primarily functions through transcriptional upregulation of ABCA1 (

CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lipidation for Synergis