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protein 1,102 words KG: NR1H3PROTEIN
Contents

LXR-alpha Protein

🔬 Protein Info
Gene SymbolLXR
Full Namealpha Protein
AliasesLiver X Receptor
Subcellular Localization</strong></td><td>Nucleus</td></tr>
PathwaysNF-κB
GeneCardsLXR
Human Protein AtlasLXR
Associated DiseasesALS, Alzheimer, glioblastoma, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsABCA1, ABCA7, ABCG1, ACAT1, AKT, AMPK
SciDEX HypothesesUpstream restoration of glial lipid efflux and apo
KG Connections103 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (14)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72APOE-Dependent Autophagy Restoration
Score: 0.85

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedGBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Neurodegeneration
disease · KG edge: implicated_innct05508789
clinical_trial · Pages share 4 hypothesesMK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypothesesA Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

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