concept

GUT MICROBIOTA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUT MICROBIOTA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

298Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	GUT MICROBIOTA

Pathway Diagram

graph TD
    GUT_MICROBIOTA["GUT MICROBIOTA"]
    GUT_MICROBIOTA -->|"modulates"| Central_Nervous_System["Central Nervous System"]
    GUT_MICROBIOTA -->|"regulates"| Gut_Brain_Axis["Gut-Brain Axis"]
    GUT_MICROBIOTA -->|"regulates"| Central_Nervous_System_Physiol["Central Nervous System Physiology"]
    GUT_MICROBIOTA -->|"causes"| Motor_Deficits["Motor Deficits"]
    GUT_MICROBIOTA -->|"causes"| Neuroinflammation["Neuroinflammation"]
    GUT_MICROBIOTA -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    GUT_MICROBIOTA -->|"causes"| Microglia_Activation["Microglia Activation"]
    GUT_MICROBIOTA -->|"product_of"| Tryptophan_Metabolites["Tryptophan Metabolites"]
    GUT_MICROBIOTA -->|"modulates"| Mood["Mood"]
    Antioxidants["Antioxidants"] -->|"modulates"| GUT_MICROBIOTA
    Neural_Pathway["Neural Pathway"] -->|"mediates"| GUT_MICROBIOTA
    Fecal_Microbial_Transplantatio["Fecal Microbial Transplantation"] -->|"targets"| GUT_MICROBIOTA
    BMAL1["BMAL1"] -->|"regulates"| GUT_MICROBIOTA

Outgoing (104)

Target	Relation	Type	Str
Gut-Brain Axis	component_of	pathway	0.95
Neuroinflammation	causes	process	0.95
Motor Deficits	causes	phenotype	0.95
Indoleacetic Acid	associated_with	compound	0.95
Parkinson'S Disease	regulates	disease	0.95
Enteric Nervous System	interacts_with	cell_type	0.95
Parkinson's Disease	associated_with	disease	0.95
Host Immunity	regulates	process	0.95
Central Nervous System	associated_with	cell_type	0.95
Host Metabolism	regulates	process	0.95
Central Nervous System Physiology	regulates	process	0.95
RNA Methylation	modulates	mechanism	0.95
Histone Modifications	modulates	mechanism	0.95
Brain Functions	associated_with	process	0.95
DNA Methylation	modulates	mechanism	0.95
Alzheimer's Disease	associated_with	disease	0.95
Gut-Brain Axis	regulates	pathway	0.95
Parkinson'S Disease	associated_with	disease	0.95
Parkinson's Disease	contributes_to	disease	0.95
Gut-Microbiome-Brain Axis	mediates	pathway	0.95
Alzheimer'S Disease	associated_with	disease	0.95
gut-brain axis	regulates	pathway	0.92
Tryptophan Metabolites	associated_with	compound	0.90
Glycerophospholipid Metabolism	regulates	pathway	0.90
Indole Derivatives	product_of	compound	0.90
Microglia Activation	causes	process	0.90
mood	regulates	phenotype	0.90
Obesity	associated_with	disease	0.90
alpha-synuclein pathology	regulates	mechanism	0.90
Mood	modulates	phenotype	0.90
N6-Methyladenosine	regulates	compound	0.90
Cognition	modulates	phenotype	0.90
Brain	modulates	cell_type	0.90
neuroinflammation	promotes	process	0.90
Glaucoma	protects_against	disease	0.90
Disease Pathogenesis	contributes_to	mechanism	0.90
Immune System	modulates	process	0.88
Metabolite Production	regulates	process	0.88
Tau-Mediated Neurodegeneration	contributes_to	process	0.88
microglia activation	regulates	process	0.88
Neuroinflammation	modulates	process	0.88
Central Nervous System Homeostasis	regulates	process	0.87
depression	associated_with	disease	0.85
HPA axis	modulates	pathway	0.85
SNCA Pathology	modulates	process	0.85
Glaucoma	associated_with	disease	0.85
PARKINSON'S DISEASE	contributes_to	disease	0.85
ALZHEIMER'S DISEASE	contributes_to	disease	0.85
Neurodevelopment	regulates	process	0.85
Systemic Inflammation	modulates	process	0.85

Incoming (194)

Source	Relation	Type	Str
Antioxidants	modulates	compound	0.95
IPA	associated_with	compound	0.95
TCM polyphenols	regulates	drug	0.90
AGING	modulates	phenotype	0.90
35010895	modify	paper	0.90
33374235	plays a crucial role in	paper	0.90
35248147	modulate	paper	0.90
33517890	required for	paper	0.90
39036341	communicates bidirectionally with	paper	0.90
39036341	regulates	paper	0.90
Neural Pathway	mediates	pathway	0.90
APOE	interacts_with	gene	0.88
fecal microbiota transplantation	modulates	drug	0.85
Postbiotics	modulates	compound	0.85
antidepressants	interacts_with	drug	0.85
vagus nerve	interacts_with	pathway	0.85
Fecal Microbial Transplantation	targets	drug	0.85
Quinic Acid	modulates	compound	0.85
Fecal Microbial Transplantation	modulates	drug	0.80
Akkermansia Muciniphila	modulates	compound	0.80
Traditional Chinese Medicine	modulates	drug	0.75
BMAL1	regulates	gene	0.70
Parkinson's disease	associated_with	disease	0.70
35361905	is connected with	paper	0.60
35361905	connected with	paper	0.60
36839287	is involved in	paper	0.60
MTOR	interacts_with	gene	0.60
37934614	associated with	paper	0.60
39036341	has potential in preventing and treating	paper	0.60
39036341	plays a role in driving	paper	0.60
35248147	affect indirectly by impacting	paper	0.60
Neuroinflammation	activates	process	0.50
NRF2	activates	gene	0.50
Cognitive Impairment	activates	phenotype	0.50
DEMENTIA	associated_with	gene	0.50
EXERCISE	regulates	concept	0.50
Insulin Resistance	activates	disease	0.50
INSULIN	activates	concept	0.50
Insulin Resistance	interacts_with	disease	0.50
INSULIN	interacts_with	concept	0.50
Autophagy	associated_with	process	0.50
NLRP6	regulates	gene	0.50
IL-18	regulates	protein	0.50
NLRP3	regulates	protein	0.50
Metabolic Syndrome	regulates	disease	0.50
NAFLD	regulates	disease	0.50
TLR9	activates	gene	0.50
NLRP6	interacts_with	gene	0.50
NLRP3	interacts_with	protein	0.50
Metabolic Syndrome	interacts_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.682

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Hypothesis debate: Microbial Inflammasome Priming Prevention

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

The debate identified a critical mechanistic gap between SCFA production by gut

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 6 · Score: 0.89 · 2026-04-01

Related Research

Hypotheses and analyses mentioning GUT MICROBIOTA in their description or question text

No additional research found