protein

NEPRILYSIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEPRILYSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

122Connections

0Hypotheses

0Analyses

50Outgoing

45Incoming

0Experiments

0Debates

Summary

NEPRILYSIN is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with ALS, Alzheimer. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NEPRILYSIN
Chromosome	3q25.2.
Protein Type	Protease
Function	is an important component in the neurobiology of neurodegenerative [diseases.
Primary Expression	Membrane-bound, presynaptic
Subcellular Localization	Membrane-bound, presynaptic
Amino Acids	750 aa
Pathways	Amyloid, Apoptosis, Blood-Brain Barrier, Epigenetic, Neuroinflammatory
GeneCards	NEPRILYSIN
Human Protein Atlas	NEPRILYSIN
Associated Diseases	Alzheimer, Alzheimer'S Disease, disease
Interactions	ACE2, AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta
KG Connections	118 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Neprilysin (NEP / CD10 / MME)

protein · 3068 words

→

Pathway Diagram

graph TD
    NEPRILYSIN["NEPRILYSIN"]
    ALS{"ALS"}
    NEPRILYSIN -->|"activates"| ALS
    Alzheimer{"Alzheimer"}
    NEPRILYSIN -->|"activates"| Alzheimer
    ALZHEIMER["ALZHEIMER"]
    NEPRILYSIN -->|"activates"| ALZHEIMER
    APP["APP"]
    NEPRILYSIN -->|"activates"| APP
    Amyloid(["Amyloid"])
    NEPRILYSIN -->|"associated with"| Amyloid
    neurodegeneration["neurodegeneration"]
    NEPRILYSIN -->|"implicated in"| neurodegeneration
    AMYLOID["AMYLOID"]
    AMYLOID -->|"associated with"| NEPRILYSIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| NEPRILYSIN
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"activates"| NEPRILYSIN
    AHR["AHR"]
    AHR -->|"activates"| NEPRILYSIN
    ALZHEIMER -->|"activates"| NEPRILYSIN
    APP -->|"activates"| NEPRILYSIN
    AND["AND"]
    AND -->|"activates"| NEPRILYSIN
    style NEPRILYSIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
amyloid-β	interacts_with	protein	0.70
Sleep Disorder	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALZHEIMER	associated_with	gene	0.60
NEP	degrades	gene	0.60
AND	degrades	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AND	regulates	gene	0.60
PER	activates	gene	0.60
Amyloid	associated_with	pathway	0.60
Ras	activates	protein	0.60
Raf	activates	protein	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
AND	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP/PS1	activates	gene	0.60
Amyloid	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
NEP	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
NEP	inhibits	gene	0.60
AND	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
EXERCISE	inhibits	gene	0.60
Astrocyte	inhibits	cell_type	0.60
ACE2	activates	gene	0.60
Apoptosis	activates	pathway	0.60
APP	activates	gene	0.60
TRKB	activates	gene	0.60
Fibronectin	inhibits	protein	0.60
ERK	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
SIRT1	activates	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
ASTROCYTES	activates	gene	0.60
AQUAPORIN-4	regulates	gene	0.60
Astrocyte	activates	cell_type	0.60
AMYLOID	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Neuroinflammatory	activates	pathway	0.60

Incoming (45)

Source	Relation	Type	Str
entities-gaba	interacts_with	wiki	0.00
irisin	activates	protein	0.70
STAT3	inhibits	protein	0.70
AHR	activates	gene	0.60
NT4	activates	gene	0.60
BDNF	activates	gene	0.60
MECP2	activates	gene	0.60
NT3	activates	gene	0.60
TAU	activates	gene	0.60
IDE	activates	gene	0.60
AMYLOID	activates	gene	0.60
NEP	activates	gene	0.60
AQUAPORIN-4	degrades	gene	0.60
STAT3	inhibits	gene	0.60
NEP	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
ERK	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
ACE2	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
GRIN2A	activates	gene	0.60
CALCINEURIN	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
APP	activates	gene	0.60
FNDC5	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AND	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEP	associated_with	gene	0.60
PER	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
STAT3	activates	gene	0.50
AQP4	regulates	gene	0.50
AQP4	activates	gene	0.50
CALCINEURIN	activates	protein	0.50
IRISIN	activates	protein	0.50
AQUAPORIN-4	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEPRILYSIN in their description or question text

No additional research found