protein 3,068 words KG: NEPRILYSIN
Contents

Neprilysin (NEP / CD10 / MME)

🔬 Protein Info
Gene SymbolNEPRILYSIN
Chromosome3q25.2.
Protein TypeProtease
Functionis an important component in the neurobiology of neurodegenerative [diseases.
Primary ExpressionMembrane-bound, presynaptic
Subcellular LocalizationMembrane-bound, presynaptic
Amino Acids750 aa
PathwaysAmyloid, Apoptosis, Blood-Brain Barrier, Epigenetic, Neuroinflammatory
GeneCardsNEPRILYSIN
Human Protein AtlasNEPRILYSIN
Associated DiseasesAlzheimer, Alzheimer'S Disease, disease
InteractionsACE2, AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta
KG Connections115 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (10)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Glycosaminoglycan Template Disruption Approach
Score: 0.60
Blood-Brain Barrier SPM Shuttle System
Score: 0.53

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (2)

AhR agonist effects on NEP expression in N2a cells
exploratory · proposed · Score: 0.90
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (5)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

AHR activates NEPRILYSIN
NEPRILYSIN activates APP
APP activates NEPRILYSIN
FNDC5 inhibits NEPRILYSIN
NEPRILYSIN inhibits STAT3
NEPRILYSIN inhibits HDAC6
NT4 activates NEPRILYSIN
BDNF activates NEPRILYSIN
MECP2 activates NEPRILYSIN
NT3 activates NEPRILYSIN

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