Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NT3 |
| Full Name | Neurotrophin 3 |
| Chromosome | 12p13.31 |
| Protein Family | Neurotrophin |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the developing and adult CNS: - Hippocampus: Highest expression in dentate gyrus and CA3 region - Cerebral cortex |
| Amino Acids | 119 aa |
| Pathways | PI3K, mTOR, mtor, MAPK |
| UniProt ID | [P20783](https://www.uniprot.org/uniprot/P20783) |
| Ensembl ID | ENSG00000185652 |
| GeneCards | NT3 |
| Human Protein Atlas | NT3 |
| Associated Diseases | neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND, APP |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NT3["NT3"]
Als{"Als"}
NT3 -->|"activates"| Als
Ms{"Ms"}
NT3 -->|"activates"| Ms
BDNF["BDNF"]
NT3 -->|"activates"| BDNF
Oxidative_Stress(["Oxidative Stress"])
NT3 -->|"activates"| Oxidative_Stress
Mitochondrial_Function(["Mitochondrial Function"])
NT3 -->|"activates"| Mitochondrial_Function
neurodegeneration["neurodegeneration"]
NT3 -->|"implicated in"| neurodegeneration
TRKB["TRKB"]
TRKB -->|"activates"| NT3
style NT3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| APP | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| AMYLOID-BETA | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
| Amyloid | activates | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| SYNAPSE | activates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Bdnf | activates | protein | 0.60 |
| NEPRILYSIN | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| TRKB | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NT3 in their description or question text
No additional research found