protein

EIF4E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

17Outgoing

15Incoming

0Experiments

0Debates

Summary

EIF4E protein involved in neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	EIF4E
Function	Eif4E Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localization	(via 4E-BP and transport proteins) Neuronal Functions: - Synaptic plasticit
Molecular Weight	25 kDa
Amino Acids	217 aa
Pathways	mtor
GeneCards	EIF4E
Human Protein Atlas	EIF4E
Associated Diseases	Glioma, Parkinson
Interactions	BCL-2, RIBOSOMAL PROTEIN S6, VEGF
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    EIF4E["EIF4E"]
    mRNA_Translation["mRNA Translation"]
    EIF4E -->|"regulates"| mRNA_Translation
    CYCS(["CYCS"])
    EIF4E -->|"associated_with"| CYCS
    Genes["Genes"]
    EIF4E -->|"associated_with"| Genes
    MTOR_SIGNALING["MTOR SIGNALING"]
    EIF4E -->|"interacts_with"| MTOR_SIGNALING
    MTORC1["MTORC1"]
    EIF4E -->|"activates"| MTORC1
    RAPAMYCIN["RAPAMYCIN"]
    EIF4E -->|"activates"| RAPAMYCIN
    MTOR(["MTOR"])
    MTOR -->|"regulates"| EIF4E
    MMP9(["MMP9"])
    MMP9 -->|"associated_with"| EIF4E
    GFAP(["GFAP"])
    GFAP -->|"associated_with"| EIF4E
    NCF1(["NCF1"])
    NCF1 -->|"associated_with"| EIF4E
    style EIF4E fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (17)

Target	Relation	Type	Str
4E-BP	interacts_with	protein	0.90
mRNA Translation	regulates	process	0.85
Parkinson	associated_with	disease	0.60
PLCG1	co_expressed_with	gene	0.50
GFAP	co_expressed_with	gene	0.50
NRAS	co_expressed_with	gene	0.50
MTORC1	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
MMP9	co_expressed_with	gene	0.50
BCL-2	activates	protein	0.50
Glioma	activates	disease	0.50
SRPK1	activates	concept	0.50
apoptosis	associated_with	process	0.50
Glioma	associated_with	disease	0.50
SRPK1	associated_with	concept	0.50
MTOR SIGNALING	interacts_with	concept	0.50
CYCS	associated_with	gene	0.50

Incoming (15)

Source	Relation	Type	Str
RIPK1	regulates	protein	0.70
MTOR	regulates	protein	0.70
VEGF	activates	gene	0.50
VEGF	associated_with	gene	0.50
CDC42	co_expressed_with	gene	0.50
CYCS	co_expressed_with	gene	0.50
CDKN2A	co_expressed_with	gene	0.50
CDKN2B	co_expressed_with	gene	0.50
MMP9	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
NCF1	associated_with	gene	0.50
CDC42	associated_with	gene	0.50
SOD2	associated_with	gene	0.50
mTOR	interacts_with	entity	0.50
RIBOSOMAL PROTEIN S6	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF4E in their description or question text

No additional research found