| Gene Symbol | EIF4E |
| Aliases | EIF4EPROTEIN |
| Function | Eif4E Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | (via 4E-BP and transport proteins) **Neuronal Functions**: - Synaptic plasticit |
| Molecular Weight | 25 kDa |
| Amino Acids | 217 aa |
| Pathways | mtor |
| GeneCards | EIF4E |
| Human Protein Atlas | EIF4E |
| Cap-Binding Pocket | Hydrophobic pocket that binds the m7G cap |
| Convex Surface | Interacts with eIF4G |
| Concave Surface | Binds to eIF4A |
| Phosphorylation Site | Ser209 (regulates mRNA binding and localization) |
| 4E-BP Binding Site | 竞争性结合4E-BP for translational regulation |
| Translation Dysregulation | Global and local translation is dysregulated in AD, with eIF4E playing a central role |
| Associated Diseases | Glioma, Parkinson |
| Interactions | BCL-2, RIBOSOMAL PROTEIN S6, VEGF |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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