gene

OTUD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OTUD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

16Outgoing

1Incoming

0Experiments

0Debates

Summary

OTUD3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in. Associated with Als, Cancer, Tumor. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OTUD3
Full Name	OTU Deubiquitinase 3
Aliases	PARK11
Chromosome	17p13.1
Function	Under physiological conditions, OTUD3 participates in several cellular processes:
Primary Expression	Brain, Heart, Kidney, Liver
Amino Acids	524 aa
Pathways	Mtor
UniProt ID	Q5T7Q2
NCBI Gene ID	57567
Ensembl ID	ENSG00000167695
OMIM	607375
GeneCards	OTUD3
Human Protein Atlas	OTUD3
Associated Diseases	Parkinson's Disease
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OTUD3 — AlphaFold Q5T7Q2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

OTUD3 — OTU Deubiquitinase 3

gene · 686 words

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Pathway Diagram

graph TD
    OTUD3["OTUD3"]
    Tumor{"Tumor"}
    OTUD3 -->|"regulates"| Tumor
    Cancer{"Cancer"}
    OTUD3 -->|"regulates"| Cancer
    Als{"Als"}
    OTUD3 -->|"regulates"| Als
    UBIQUITIN(["UBIQUITIN"])
    OTUD3 -->|"regulates"| UBIQUITIN
    PI3K(["PI3K"])
    OTUD3 -->|"regulates"| PI3K
    USP7(["USP7"])
    OTUD3 -->|"regulates"| USP7
    PTEN(["PTEN"])
    PTEN -->|"regulates"| OTUD3
    style OTUD3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (16)

Target	Relation	Type	Str
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
USP11	regulates	gene	0.60
Mtor	regulates	pathway	0.60
CANCER	regulates	gene	0.60
GENES	regulates	gene	0.60
PTEN	regulates	gene	0.60
USP13	regulates	gene	0.60
cancer	regulates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
UBIQUITIN	regulates	gene	0.60
PI3K	regulates	gene	0.60
USP7	regulates	gene	0.60
AKT	regulates	gene	0.60
MTOR	regulates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
PTEN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OTUD3 in their description or question text

No additional research found