gene 2,035 words KG: RRM2B
Contents

RRM2B Gene

🧬 Gene Info
Gene SymbolRRM2B
Full NameRibonucleotide Reductase Regulatory TP53 Inducible Subunit M2B
AliasesRRM2B gene encoding p53-inducible ribonucleotide reductase subunit M2B
Chromosome8q23.1
Protein TypeEnzyme
Functionencodes a critical enzyme in nucleotide metabolism, specifically the p53-inducible small subunit of ribonucleotide reductase (RNR).
Primary Expressionmost human tissues, with highest levels in: - Skeletal muscle: High mitochondrial content and energy demand - Heart: Continuous oxidative phos
Molecular Weight45 kDa
Amino Acids389 aa
UniProt IDQ7LG56
NCBI Gene ID50484
Ensembl IDENSG00000068912
OMIM604712
GeneCardsRRM2B
Human Protein AtlasRRM2B
Associated Diseasesneurodegeneration
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Mitochondria
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: associated_with
DGUOK — Deoxyguanosine Kinase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

POLG2 associated_with RRM2B
SLC25A4 associated_with RRM2B
MFN2 associated_with RRM2B
TYMP associated_with RRM2B
RRM2B associated_with TK2
RRM2B associated_with SUCLA2
RRM2B associated_with SUCLG1
RRM2B associated_with TFAM
RRM2B associated_with POLG
RRM2B associated_with RNASEH1

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