gene 1,130 words KG: PANK2
Contents

PANK2 — Pantothenate Kinase 2

🧬 Gene Info
Gene SymbolPANK2
Full NamePantothenate Kinase 2
Chromosome20p13
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionHigh in brain, especially basal ganglia
Subcellular Localizationthe mitochondrial matrix. It catalyzes the first and rate-limiting step in CoA biosynthesis, the phosphorylation of vita
Molecular Weight57 kDa
Amino Acids570 aa
UniProt IDQ9C0B0
NCBI Gene ID80025
Ensembl IDENSG00000125779
OMIM606157
GeneCardsPANK2
Human Protein AtlasPANK2
Associated DiseasesAging, Als, Dystonia, Ms, neurodegeneration
InteractionsATP13A2, CP, DCAF17, FA2H, FTL, PLA2G6
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Parkinson Basal Ganglia Circuit
circuit · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: associated_with

Knowledge Graph (12 edges)

PLA2G6 associated_with PANK2
FTL associated_with PANK2
WDR45 associated_with PANK2
COASY associated_with PANK2
DCAF17 associated_with PANK2
FA2H associated_with PANK2
C19ORF12 associated_with PANK2
PANK2 associated_with PLA2G6
PANK2 therapeutic_target MAX
PANK2 therapeutic_target BID

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