concept

GUT MICROBIOTA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUT MICROBIOTA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

298Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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💡 Concept Info

Name	GUT MICROBIOTA

Pathway Diagram

graph TD
    GUT_MICROBIOTA["GUT MICROBIOTA"]
    GUT_MICROBIOTA -->|"modulates"| Central_Nervous_System["Central Nervous System"]
    GUT_MICROBIOTA -->|"regulates"| Gut_Brain_Axis["Gut-Brain Axis"]
    GUT_MICROBIOTA -->|"regulates"| Central_Nervous_System_Physiol["Central Nervous System Physiology"]
    GUT_MICROBIOTA -->|"causes"| Motor_Deficits["Motor Deficits"]
    GUT_MICROBIOTA -->|"causes"| Neuroinflammation["Neuroinflammation"]
    GUT_MICROBIOTA -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    GUT_MICROBIOTA -->|"causes"| Microglia_Activation["Microglia Activation"]
    GUT_MICROBIOTA -->|"product_of"| Tryptophan_Metabolites["Tryptophan Metabolites"]
    GUT_MICROBIOTA -->|"modulates"| Mood["Mood"]
    Antioxidants["Antioxidants"] -->|"modulates"| GUT_MICROBIOTA
    Neural_Pathway["Neural Pathway"] -->|"mediates"| GUT_MICROBIOTA
    Fecal_Microbial_Transplantatio["Fecal Microbial Transplantation"] -->|"targets"| GUT_MICROBIOTA
    BMAL1["BMAL1"] -->|"regulates"| GUT_MICROBIOTA

Outgoing (104)

Target	Relation	Type	Str
Motor Deficits	causes	phenotype	0.95
Enteric Nervous System	interacts_with	cell_type	0.95
Neuroinflammation	causes	process	0.95
Gut-Brain Axis	regulates	pathway	0.95
Central Nervous System Physiology	regulates	process	0.95
Gut-Microbiome-Brain Axis	mediates	pathway	0.95
Parkinson's Disease	contributes_to	disease	0.95
DNA Methylation	modulates	mechanism	0.95
Histone Modifications	modulates	mechanism	0.95
Central Nervous System	associated_with	cell_type	0.95
Gut-Brain Axis	component_of	pathway	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Brain Functions	associated_with	process	0.95
Parkinson'S Disease	associated_with	disease	0.95
Host Metabolism	regulates	process	0.95
Parkinson'S Disease	regulates	disease	0.95
RNA Methylation	modulates	mechanism	0.95
Alzheimer's Disease	associated_with	disease	0.95
Host Immunity	regulates	process	0.95
Indoleacetic Acid	associated_with	compound	0.95
Parkinson's Disease	associated_with	disease	0.95
gut-brain axis	regulates	pathway	0.92
alpha-synuclein pathology	regulates	mechanism	0.90
mood	regulates	phenotype	0.90
Glaucoma	protects_against	disease	0.90
Obesity	associated_with	disease	0.90
Disease Pathogenesis	contributes_to	mechanism	0.90
Glycerophospholipid Metabolism	regulates	pathway	0.90
Tryptophan Metabolites	associated_with	compound	0.90
neuroinflammation	promotes	process	0.90
Brain	modulates	cell_type	0.90
Indole Derivatives	product_of	compound	0.90
Microglia Activation	causes	process	0.90
N6-Methyladenosine	regulates	compound	0.90
Mood	modulates	phenotype	0.90
Cognition	modulates	phenotype	0.90
Metabolite Production	regulates	process	0.88
Immune System	modulates	process	0.88
Neuroinflammation	modulates	process	0.88
microglia activation	regulates	process	0.88
Tau-Mediated Neurodegeneration	contributes_to	process	0.88
Central Nervous System Homeostasis	regulates	process	0.87
Neuroinflammation	regulates	process	0.85
Microglia Activation	modulates	process	0.85
HPA axis	modulates	pathway	0.85
depression	associated_with	disease	0.85
Central Nervous System	interacts_with	structure	0.85
SNCA Pathology	modulates	process	0.85
PARKINSON'S DISEASE	contributes_to	disease	0.85
ALZHEIMER'S DISEASE	contributes_to	disease	0.85

Incoming (194)

Source	Relation	Type	Str
IPA	associated_with	compound	0.95
Antioxidants	modulates	compound	0.95
35248147	modulate	paper	0.90
Neural Pathway	mediates	pathway	0.90
33374235	plays a crucial role in	paper	0.90
39036341	communicates bidirectionally with	paper	0.90
39036341	regulates	paper	0.90
35010895	modify	paper	0.90
AGING	modulates	phenotype	0.90
TCM polyphenols	regulates	drug	0.90
33517890	required for	paper	0.90
APOE	interacts_with	gene	0.88
Fecal Microbial Transplantation	targets	drug	0.85
Postbiotics	modulates	compound	0.85
fecal microbiota transplantation	modulates	drug	0.85
vagus nerve	interacts_with	pathway	0.85
antidepressants	interacts_with	drug	0.85
Quinic Acid	modulates	compound	0.85
Akkermansia Muciniphila	modulates	compound	0.80
Fecal Microbial Transplantation	modulates	drug	0.80
Traditional Chinese Medicine	modulates	drug	0.75
Parkinson's disease	associated_with	disease	0.70
BMAL1	regulates	gene	0.70
MTOR	interacts_with	gene	0.60
35361905	is connected with	paper	0.60
35361905	connected with	paper	0.60
36839287	is involved in	paper	0.60
39036341	has potential in preventing and treating	paper	0.60
39036341	plays a role in driving	paper	0.60
35248147	affect indirectly by impacting	paper	0.60
37934614	associated with	paper	0.60
Liver Cancer	interacts_with	disease	0.50
TUMOR	activates	disease	0.50
APP/PS1	activates	concept	0.50
Hippocampus	activates	entity	0.50
apoptosis	activates	process	0.50
Neuroinflammation	regulates	process	0.50
PARKINSON	regulates	gene	0.50
Parkinson's Disease	regulates	disease	0.50
disease	regulates	disease	0.50
PARKINSON'S	regulates	concept	0.50
Microbiota	regulates	process	0.50
microglia	activates	cell_type	0.50
Microbiota	activates	process	0.50
Microbiota	associated_with	process	0.50
DEPRESSION	associated_with	disease	0.50
STROKE	associated_with	gene	0.50
Dna Methylation	regulates	pathway	0.50
DEPRESSION	interacts_with	disease	0.50
STROKE	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.682

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Hypothesis debate: Microbial Inflammasome Priming Prevention

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

The debate identified a critical mechanistic gap between SCFA production by gut

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 6 · Score: 0.89 · 2026-04-01

Related Research

Hypotheses and analyses mentioning GUT MICROBIOTA in their description or question text

No additional research found