gene

CBLN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CBLN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

10Outgoing

6Incoming

0Experiments

0Debates

Summary

CBLN1 (Cerebellin 1): secreted synaptogenic protein essential for parallel fiber-Purkinje cell synapse formation, motor learning, and cerebellar development. Implicated in cerebellar ataxia, autism spectrum disorder, and schizophrenia.

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🧬 Gene Info

Gene Symbol	CBLN1
Full Name	Cerebellin 1
Chromosome	16q24.1
Protein Family	Cerebellin family (C1q family)
Protein Type	Receptor
Function	encodes a secreted glycoprotein that functions as a critical synaptogenic molecule in the central nervous system, particularly in the cerebellum.
Amino Acids	595 aa
UniProt ID	Q9ULM3
NCBI Gene ID	114825
Ensembl ID	ENSG00000102970
OMIM	604349
GeneCards	CBLN1
Human Protein Atlas	CBLN1
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AUTOPHAGY, BECN1, GLUD1, GRID1, LAMP1, MAP1LC3B
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CBLN1 — AlphaFold Q9ULM3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CBLN1 Gene

gene · 1688 words

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Pathway Diagram

graph TD
    CBLN1["CBLN1"]
    Ms{"Ms"}
    CBLN1 -->|"inhibits"| Ms
    BECN1["BECN1"]
    CBLN1 -->|"inhibits"| BECN1
    Autophagy(["Autophagy"])
    CBLN1 -->|"inhibits"| Autophagy
    SQSTM1["SQSTM1"]
    CBLN1 -->|"inhibits"| SQSTM1
    GLUD1["GLUD1"]
    CBLN1 -->|"interacts with"| GLUD1
    MAP1LC3B["MAP1LC3B"]
    CBLN1 -->|"inhibits"| MAP1LC3B
    LAMP1["LAMP1"]
    CBLN1 -->|"inhibits"| LAMP1
    GRID1["GRID1"]
    CBLN1 -->|"inhibits"| GRID1
    PRKCD["PRKCD"]
    CBLN1 -->|"inhibits"| PRKCD
    AND["AND"]
    CBLN1 -->|"inhibits"| AND
    AUTOPHAGY["AUTOPHAGY"]
    CBLN1 -->|"inhibits"| AUTOPHAGY
    neurodegeneration["neurodegeneration"]
    CBLN1 -->|"implicated in"| neurodegeneration
    SQSTM1 -->|"inhibits"| CBLN1
    MAP1LC3B -->|"inhibits"| CBLN1
    GRID1 -->|"inhibits"| CBLN1
    GLUD1 -->|"interacts with"| CBLN1
    LAMP1 -->|"inhibits"| CBLN1
    PRKCD -->|"inhibits"| CBLN1
    style CBLN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
BECN1	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
GLUD1	interacts_with	gene	0.60
MAP1LC3B	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
GRID1	inhibits	gene	0.60
PRKCD	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
AUTOPHAGY	inhibits	gene	0.60

Incoming (6)

Source	Relation	Type	Str
SQSTM1	inhibits	gene	0.60
MAP1LC3B	inhibits	gene	0.60
GRID1	inhibits	gene	0.60
GLUD1	interacts_with	gene	0.60
LAMP1	inhibits	gene	0.60
PRKCD	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CBLN1 in their description or question text

No additional research found